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[下丘脑后部施加电流的家兔小脑皮质的变化]

[Changes in the cerebellar cortex of rabbits subjected to an electrical current on the posterior hypothalamus].

作者信息

Taiushev K G, Shustova T I, Kaganovskaia E A

出版信息

Arkh Anat Gistol Embriol. 1985 Nov;89(11):5-12.

PMID:4091669
Abstract

After 3, 15 and 30 sessions of electrical stimulation of the hypothalamus by means of stereotaxically implanted bipolar electrodes into the area hypothalamica posterior, in the cortex of the cerebellar hemispheres, predominantly in the ganglionic layer, certain reactive, as well as poorly and intensively manifested pathological changes develop in neural and glial cells. Mosaicism of Purkinje's cells lesions within the layer, the state of their cytoplasmic matrix, granular endoplasmic reticulum and mitochondria, essential shifts in activity of oxidation-reduction enzymes at a simultaneous disorder in blood circulation and decreased content of catecholamines in the neural structures of the cerebellar vessels make it possible to estimate the process as centrogenic and neurodistrophic.

摘要

通过立体定向将双极电极植入下丘脑后部区域,对下丘脑进行3次、15次和30次电刺激后,在小脑半球皮质,主要是神经节层,神经和神经胶质细胞中出现了某些反应性以及表现较弱和较强的病理变化。该层内浦肯野细胞病变的镶嵌现象、其细胞质基质、颗粒内质网和线粒体的状态、氧化还原酶活性的显著变化,同时伴有血液循环紊乱以及小脑血管神经结构中儿茶酚胺含量降低,使得将该过程评估为中枢性和神经营养不良性成为可能。

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