Sadílková M, Fremuth F
Folia Biol (Praha). 1976;22(5):330-4.
By means of radioprotection, it was shown that a correlation exists after LD 50/30 between radiation-induced changes in cellular proliferation of critical radiosensitive tissue (bone marrow) and lethality, both in the time course and in the degree of the effect. Close correspondence between proliferation changes after irradiation and radiation lethality indicates that the inhibition of proliferation activity may play a major role in the mechanism of the death of irradiated organisms. A modification of cellular proliferation results in a change in radiation mortality. Pretreatment with the radioprotective compound AET leads to a moderation of both the inhibitory effect of radiation upon proliferation and radiation lethality.
通过辐射防护研究表明，在半数致死剂量（LD 50/30）之后，关键放射敏感组织（骨髓）的细胞增殖辐射诱导变化与致死率之间在时间进程和效应程度上均存在相关性。照射后增殖变化与辐射致死率之间的密切对应表明，增殖活性的抑制可能在受照生物体死亡机制中起主要作用。细胞增殖的改变导致辐射死亡率的变化。用辐射防护化合物AET进行预处理可使辐射对增殖的抑制作用和辐射致死率均得到缓解。
