Peterson M S, Murakami T, Baron R L
Department of Radiology, University of Pittsburgh Medical Center, PA 15213-2582, USA.
Abdom Imaging. 1998 Nov-Dec;23(6):592-9. doi: 10.1007/s002619900410.
To determine the spectrum of appearances of gadolinium retention within cholangiocarcinoma (CCA) and other liver neoplasms.
Two hundred ten patients underwent hepatic magnetic resonance imaging (MRI) at 1.5 T with precontrast T1- and T2-weighted spin-echo (SE) images and delayed Gd-DTPA- or gadoteridol- (0.1 mmol/kg) enhanced T1-weighted SE images. Postcontrast images were evaluated for lesions suspicious for tumors, and lesion signal intensity was characterized as homogeneously or heterogeneously hypo-, iso-, mildly hyper-, or markedly hyperintense to liver. Data from 94 patients with benign or malignant neoplasms are presented.
Imaging demonstrated 237 malignant neoplasms (121 hepatocellular carcinoma [HCC], 26 CCA, 17 colon carcinoma metastases, 73 other tumors) and 28 benign neoplasms (22 hemangioma, six focal nodular hyperplasia [FNH]). One hundred forty malignant lesions appeared as homogeneous postcontrast (29 hypointense, 75 isointense, 17 mildly hyperintense, 19 markedly hyperintense) and 97 as heterogeneous (15 isointense, 50 mildly hyperintense, 32 markedly hyperintense). Malignant lesions showing homogeneous, mildly or markedly hyperintense signal intensity postcontrast included 10 CCA, seven HCC, six epithelioid hemangioendothelioma, eight neuroendocrine tumor metastases, three adenocarcinoma metastases of unknown origin, and one breast carcinoma metastasis. Hemangiomas appeared as homogeneous postcontrast in 19 lesions (six isointense, one mildly hyperintense, 12 markedly hyperintense) and as heterogeneous in three lesions (markedly hyperintense). FNH appeared as homogeneous postcontrast in one lesion (isointense) and as heterogeneous in five lesions (one isointense, four mildly hyperintense).
Homogeneous gadolinium retention on delayed postcontrast images of malignant hepatic neoplasms is seen in a high percentage of CCA lesions and less commonly with other neoplasms.
确定钆在胆管癌（CCA）及其他肝脏肿瘤中的留存表现谱。
210例患者接受了1.5T的肝脏磁共振成像（MRI）检查，包括对比剂前的T1加权和T2加权自旋回波（SE）图像，以及延迟钆喷酸葡胺或钆特醇（0.1 mmol/kg）增强后的T1加权SE图像。对对比剂增强后的图像进行评估，以确定可疑肿瘤病变，并将病变信号强度特征化为相对于肝脏均匀或不均匀的低、等、轻度高或明显高信号。本文展示了94例良性或恶性肿瘤患者的数据。
影像学检查显示237个恶性肿瘤（121个肝细胞癌[HCC]、26个CCA、17个结肠癌转移灶、73个其他肿瘤）和28个良性肿瘤（22个血管瘤、6个局灶性结节性增生[FNH]）。140个恶性病变在对比剂增强后表现为均匀信号（29个低信号、75个等信号、17个轻度高信号、19个明显高信号），97个表现为不均匀信号（15个等信号、50个轻度高信号、32个明显高信号）。对比剂增强后表现为均匀、轻度或明显高信号强度的恶性病变包括10个CCA、7个HCC、6个上皮样血管内皮瘤、8个神经内分泌肿瘤转移灶、3个不明来源的腺癌转移灶和1个乳腺癌转移灶。血管瘤在19个病变中对比剂增强后表现为均匀信号（6个等信号、1个轻度高信号、12个明显高信号），3个病变表现为不均匀信号（明显高信号）。FNH在1个病变中对比剂增强后表现为均匀信号（等信号），5个病变表现为不均匀信号（1个等信号、4个轻度高信号）。
在恶性肝脏肿瘤的延迟对比剂增强图像上，高比例的CCA病变可见均匀钆留存，其他肿瘤则较少见。
