de Mello e Silva A C, Boulos M
Faculdade de Medicina da Universidade de São Paulo.
Rev Hosp Clin Fac Med Sao Paulo. 1998 Jul-Aug;53(4):202-4.
The increase of rheumatic disorders in HIV infected has been known for the last decade with special emphasis on Reiter's Syndrome. In spite of common sources of HIV and other microorganisms being important in the pathogenesis of Reiter's Syndrome, severe immunodeficiency may be important in the development of rheumatic diseases, mainly because of the presence of arthritogenic microorganisms. The decrease of TCD4 lymphocytes, the increase of TCD8 lymphocytes and the modification of immune regulation may be important in the pathogenesis of Reiter's Syndrome in patients infected by HIV. There is no clinical response to nonhormonal anti-inflammatory drugs in the treatment of this entity.
在过去十年中，已知HIV感染者中风湿性疾病有所增加，其中特别强调赖特综合征。尽管HIV和其他微生物的共同来源在赖特综合征的发病机制中很重要，但严重免疫缺陷在风湿性疾病的发展中可能也很重要，主要是因为存在致关节炎微生物。TCD4淋巴细胞减少、TCD8淋巴细胞增加以及免疫调节改变在HIV感染患者的赖特综合征发病机制中可能很重要。在治疗这种疾病时，非甾体抗炎药没有临床疗效。
