Smallwood R A, Hoffman N E
Gastroenterology. 1976 Dec;71(6):1064-6.
The effect of bile acid structure on biliary lipid composition was studied on the anesthetized bile fistula cat. The sodium salts of taurocholic acid, taurodeoxycholic acid, and taurochenodeoxycholic acid were infused intravenously in 6 animals in random order in a Latin square design. Bile acids were infused for 2 hr at approximately 270 mumoles per hr; each bile acid period was preceded by a 1-hr infusion of isotonic NaCl. Bile samples from the 2nd hr of bile acid infusion, a period of steady bile acid secretion, were compared, and their bile acid, cholesterol, and phospholipid contents were measured. Mean bile acid secretion rates did not differ among the three bile acids, nor did mean phospholipd secretion rates. In contrast, cholesterol secretion was 3 to 4 times greater with the dihydroxy bile acids than with the trihydroxy bile acid, taurocholic acid. It is concluded that bile acid structure is an important determinant of the lipid composition of bile. Further, this comparison of bile acids has dissociated cholesterol from phospholipid secretion, suggesting that bile acids may influence cholesterol and phospholipid secretion independently.
在麻醉的胆瘘猫身上研究了胆汁酸结构对胆汁脂质成分的影响。采用拉丁方设计，将牛磺胆酸、牛磺脱氧胆酸和牛磺鹅去氧胆酸的钠盐以随机顺序静脉注射给6只动物。以每小时约270微摩尔的速度静脉注射胆汁酸2小时；每个胆汁酸注射期之前先静脉注射1小时等渗氯化钠。比较了胆汁酸注射第2小时（胆汁酸分泌稳定期）的胆汁样本，并测定了其中胆汁酸、胆固醇和磷脂的含量。三种胆汁酸的平均胆汁酸分泌率没有差异，平均磷脂分泌率也没有差异。相比之下，二羟基胆汁酸的胆固醇分泌量比三羟基胆汁酸牛磺胆酸高3至4倍。得出的结论是，胆汁酸结构是胆汁脂质成分的重要决定因素。此外，对胆汁酸的这种比较将胆固醇分泌与磷脂分泌区分开来，表明胆汁酸可能独立影响胆固醇和磷脂的分泌。
