Afrasyap L, Güvenen G, Türkmen S
Biochemistry and Clinical Biochemistry, PTT Hospital, Ustbostanci-Istanbul, Turkiye.
Cancer Biochem Biophys. 1998 Jun;16(1-2):129-38.
The study was carried out on 25 women with breast cancer, 25 with fibrocystic breast disease and 19 healthy subjects. Antioxidant enzyme activities and total antioxidant status (AOX) were measured in erythrocyte and plasma of patients and healthies. Among the studied parameters, the erythrocyte Glutathione Peroxidase (GSH-Px) and Catalase (CAT) activities of patients with breast cancer were significantly different as compared to the control group values (p < 0.002 and p < 0.001) respectively. There was no correlation between total antioxidant status and any of these enzymes in erythrocyte and plasma activities of subjects. However, the positive correlation was found between erythrocyte and plasma Superoxide Dismutase [SOD(CuZn)] activities in all groups. Our results indicate that enzymatic and nonenzymatic antioxidants are differentially altered in human breast tumors. Since the total antioxidant status measurement isn't sufficient to evaluate the oxidant damage in breast disease, antioxidant enzymes must be measured separately in order to get additional information.
该研究对25名乳腺癌患者、25名纤维囊性乳腺病患者和19名健康受试者进行。测量了患者和健康者红细胞及血浆中的抗氧化酶活性和总抗氧化状态（AOX）。在所研究的参数中，乳腺癌患者的红细胞谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）活性与对照组相比有显著差异（分别为p < 0.002和p < 0.001）。在受试者的红细胞和血浆活性中，总抗氧化状态与这些酶中的任何一种均无相关性。然而，在所有组中，红细胞和血浆超氧化物歧化酶[SOD（CuZn）]活性之间存在正相关。我们的结果表明，人类乳腺肿瘤中酶促和非酶促抗氧化剂发生了不同程度的改变。由于总抗氧化状态测量不足以评估乳腺疾病中的氧化损伤，因此必须分别测量抗氧化酶以获取更多信息。
