铜绿假单胞菌中染色体β-内酰胺酶与MexAB-OprM外排系统在对β-内酰胺类抗生素固有耐药性中的相互作用。
Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.
作者信息
Masuda N, Gotoh N, Ishii C, Sakagawa E, Ohya S, Nishino T
机构信息
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1999 Feb;43(2):400-2. doi: 10.1128/AAC.43.2.400.
Abstract
We investigated the role of chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa. Determination of the susceptibilities of a series of isogenic mutants with impaired production of the beta-lactamase and the efflux system to 16 beta-lactams including penicillins, cephems, oxacephems, carbapenems, and a monobactam demonstrated that the intrinsic resistance of P. aeruginosa to most of the beta-lactams is due to the interplay of both factors.
摘要
我们研究了染色体β-内酰胺酶和MexAB-OprM外排系统在铜绿假单胞菌对β-内酰胺类抗生素固有耐药性中的作用。测定了一系列β-内酰胺酶和外排系统产生受损的同基因突变体对16种β-内酰胺类抗生素（包括青霉素类、头孢菌素类、氧头孢烯类、碳青霉烯类和单环β-内酰胺类）的敏感性，结果表明铜绿假单胞菌对大多数β-内酰胺类抗生素的固有耐药性是这两种因素相互作用的结果。
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