Antona V, Cammarata G, De Gregorio L, Dragani T A, Giallongo A, Feo S
Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo, Palermo (Italy).
Cytogenet Cell Genet. 1998;83(1-2):90-2. doi: 10.1159/000015138.
We have recently identified and characterized a Kruppel-like zinc finger protein (BERF-1), that functions as a repressor of beta enolase gene transcription. By interspecific backcross analysis the gene encoding BERF-1 was localized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an isolated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal to the D8Mit4 marker. Nucleotide sequence identity and chomosome location indicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF148 localized to human chromosome 3q21, a common translocation site in acute myeloid leukemia patients.
我们最近鉴定并表征了一种类 Kruppel 锌指蛋白（BERF-1），它作为β烯醇化酶基因转录的抑制因子发挥作用。通过种间回交分析，编码 BERF-1 的基因定位于小鼠 16 号染色体上 Mtv6 基因座近端 4.7 cM 处，一个分离的假基因定位于小鼠 8 号染色体上，距离 D8Mit4 标记约 5.3 cM 远。核苷酸序列同一性和染色体定位表明，编码 BERF-1 的基因是定位于人类 3q21 染色体上的 ZNF148 的小鼠同源物（Zfp148），3q21 是急性髓性白血病患者常见的易位位点。
