[从人脑中纯化两种琥珀酸半醛还原酶]

[Purification of 2 succinic semi-aldehyde reductases from the human brain].

作者信息

Cash C, Maitre M, Mandel P

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Jun 19;286(24):1829-32.

Abstract

Two succinic semi-aldehyde reductases (A and B) have been purified to electrophoretic homogeneity. Enzyme A, which is a monomer of molecular weight 40,000 +/- 5,000 reduces a wide range of aldehydes and is inhibited by some barbiturates and certain anticonvulsants. Enzyme B, which is a dimer of molecular weight 80,000 +/- 10,000, is very specific for succinic semi-aldehyde and is not inhibited by the aforementioned compounds.

摘要

两种琥珀酸半醛还原酶（A和B）已被纯化至电泳纯。酶A是一种分子量为40,000±5,000的单体，能还原多种醛类，且受到某些巴比妥酸盐和特定抗惊厥药的抑制。酶B是一种分子量为80,000±10,000的二聚体，对琥珀酸半醛具有高度特异性，不受上述化合物的抑制。