Zhang J, Shen-Ong G, Ostell J
National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894 USA.
Genome Res. 1999 Jan;9(1):91-8.
KARIBIN () is a karyotypic region-based integrated information resource that provides a comprehensive view of the integrated mapping and sequencing data for the human genome. A cytogenetic band is linked to a genetic or physical location using fluorescence in situ hybridization (FISH) mapping data. The genetic, physical mapping data and the sequencing data are integrated using STS markers positioned on multiple maps. For each cytogenetic band, the user can obtain the most up-to-date information that includes genetic and physical maps, human transcript gene map, YAC and PAC/BAC clone coverage, disease gene phenotype, and high throughput genomic sequences from the major human genome sequencing centers. This information provides a framework for future experiments and may accelerate the process of disease gene hunting. It is envisioned that other cytogenetic-based information such as chromosome aberrations can be linked to this framework.
KARIBIN()是一个基于核型区域的综合信息资源,它提供了人类基因组综合图谱和测序数据的全面视图。利用荧光原位杂交(FISH)图谱数据,将细胞遗传学带与基因或物理位置相联系。遗传、物理图谱数据和测序数据通过定位在多个图谱上的STS标记进行整合。对于每个细胞遗传学带,用户可以获取最新信息,包括遗传和物理图谱、人类转录本基因图谱、YAC和PAC/BAC克隆覆盖范围、疾病基因表型,以及来自主要人类基因组测序中心的高通量基因组序列。这些信息为未来的实验提供了一个框架,并可能加速疾病基因搜寻的过程。预计其他基于细胞遗传学的信息,如染色体畸变,也可以与这个框架相联系。