Lindholm D, Skoglösa Y, Takei N
Department of Developmental Neuroscience, Uppsala University, Sweden.
Ann N Y Acad Sci. 1998 Dec 11;865:189-96. doi: 10.1111/j.1749-6632.1998.tb11178.x.
To function as a trophic factor PACAP and PACAP-R must be expressed in the nervous system during early development. We report here on the distribution of PACAP mRNA in the developing nervous system of the rat and compare its expression with that of PACAP-R. We discuss primary neuron culture experiments that study the neurotrophic activity of PACAP. Experimental results that indicate the presence of PACAP and its receptor in the developing nervous system, together with the observed neuropeptide activity on various populations of neurons, support the view that PACAP exhibits important neurotrophic activities comparable to those of the classical neurotrophic factors.
为发挥营养因子的作用，垂体腺苷酸环化酶激活肽（PACAP）及其受体必须在早期发育过程中于神经系统中表达。我们在此报告PACAP mRNA在大鼠发育中的神经系统中的分布，并将其表达与PACAP受体的表达进行比较。我们讨论了研究PACAP神经营养活性的原代神经元培养实验。表明PACAP及其受体存在于发育中的神经系统中的实验结果，以及观察到的神经肽对各种神经元群体的活性，支持了PACAP具有与经典神经营养因子相当的重要神经营养活性这一观点。
