Obi F O, Usenu I A, Osayande J O
Department of Biochemistry, Faculty of Science, University of Benin, Edo State, Nigeria.
Toxicology. 1998 Nov 16;131(2-3):93-8. doi: 10.1016/s0300-483x(98)00119-x.
The ability of anthocyanin obtained from the petals of H. rosasinensis to prevent carbon tetrachloride-induced acute liver damage in the rat was examined. Treatment of separate groups of rats with 2.5 ml of 1, 5 and 10% anthocyanin extract in 5% aqueous ethanol/kg body weight, 5 days/week for 4 weeks before 0.5 ml/kg carbon tetrachloride (CCL4) resulted in significantly (P < 0.05) less hepatotoxicity than with CCL4 alone, as measured by serum aspartate and alanine aminotransferase activities 18 h after CCL4. These data suggest that H. rosasinensis anthocyanin may be protective against carbon tetrachloride-induced liver injury.
研究了从朱槿花瓣中提取的花青素预防四氯化碳诱导的大鼠急性肝损伤的能力。在给予0.5 ml/kg四氯化碳（CCL4）前，将单独的大鼠组每周5天、连续4周用2.5 ml 5%乙醇水溶液中1%、5%和10%的花青素提取物按体重/千克进行处理，结果显示，在CCL4处理18小时后，通过血清天冬氨酸和丙氨酸转氨酶活性测定，与单独使用CCL4相比，肝毒性显著降低（P < 0.05）。这些数据表明，朱槿花青素可能对四氯化碳诱导的肝损伤具有保护作用。
