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Infect Immun. 1976 Oct;14(4):948-50. doi: 10.1128/iai.14.4.948-950.1976.
2
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本文引用的文献

1
DETERMINATION OF SERUM CHLORPROMAZINE METABOLITES IN PSYCHOTIC PATIENTS.精神病患者血清中氯丙嗪代谢物的测定
J Nerv Ment Dis. 1964 Oct;139:381-6. doi: 10.1097/00005053-196410000-00011.
2
Untoward reactions to tranquilizing drugs.
Am J Psychiatry. 1957 Feb;113(8):745. doi: 10.1176/ajp.113.8.745.
3
Management of the side effect of reserpine and combined reserpine-chlorpromazine treatment.利血平及利血平-氯丙嗪联合治疗的副作用管理。
Dis Nerv Syst. 1956 Nov;17(11):352-8.
4
Distribution of chlorpromazine metabolites in selected organs of psychiatric patients chronically dosed up to the time of death.直至死亡时长期给药的精神病患者选定器官中氯丙嗪代谢物的分布。
Biochem Pharmacol. 1968 Oct;17(10):2061-70. doi: 10.1016/0006-2952(68)90180-9.
5
Studies of delayed-action medication. V. Plasma levels and urinary excretion of four different dosage forms of chlorpromazine.长效药物研究。五、四种不同剂型氯丙嗪的血浆浓度及尿排泄情况
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):49-59. doi: 10.1002/cpt197011149.
6
Short-term effect of chlorpromazine on human leukocytes and erythrocytes. An electron microscopic study.氯丙嗪对人白细胞和红细胞的短期影响。一项电子显微镜研究。
Ann Med Exp Biol Fenn. 1972;50(1):42-8.
7
Factors affecting the inhibition of phagocytosis by chlorpromazine.影响氯丙嗪对吞噬作用抑制的因素。
Ann Med Exp Biol Fenn. 1972;50(1):37-41.
8
Effect of phenothiazines and related compounds on phagocytosis and bacterial killing by human neutrophilic leukocytes.
Ann Med Exp Biol Fenn. 1972;50(1):24-36.
9
The membrane actions of anesthetics and tranquilizers.麻醉剂和镇静剂的膜作用。
Pharmacol Rev. 1972 Dec;24(4):583-655.
10
Differential effects of chlorpromazine on the in vitro generation and effector function of cytotoxic lymphocytes.氯丙嗪对细胞毒性淋巴细胞的体外生成及效应功能的不同作用
J Exp Med. 1976 Jan 1;143(1):232-7. doi: 10.1084/jem.143.1.232.

吩噻嗪类及相关化合物对人中性粒细胞体外趋化性的抑制作用。

Inhibition of human neutrophil chemotaxis in vitro by phenothiazines and related compounds.

作者信息

Björkstén B, Quie P G

出版信息

Infect Immun. 1976 Oct;14(4):948-50. doi: 10.1128/iai.14.4.948-950.1976.

DOI:10.1128/iai.14.4.948-950.1976
PMID:992875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415476/
Abstract

Chlorpromazine (CPZ) and three other phenothiazines and the structurally related antidepressant drugs imipramine and amitriptyline were found to depress human neutrophil chemotactic responsiveness. A 7 X 10(-6)M solution of CPZ inhibited chemotaxis, whereas concentrations of the other tested drugs 10 to 1,000 times greater than this were needed to inhibit chemotaxis. This effect of CPZ could not, however, be demonstrated when testing neutrophils from patients treated with the drug. The inhibition of chemotaxis was reversible when CPZ-incubated neutrophils were washed before testing for chemotactic responsiveness. CPZ affects neutrophil funcjtion as well as other aspects of immune response.

摘要

已发现氯丙嗪（CPZ）以及其他三种吩噻嗪类药物和结构相关的抗抑郁药丙咪嗪和阿米替林会抑制人类中性粒细胞的趋化反应性。7×10⁻⁶M的CPZ溶液可抑制趋化作用，而其他受试药物的浓度需比此浓度高10至1000倍才能抑制趋化作用。然而，在用该药物治疗的患者的中性粒细胞进行测试时，无法证明CPZ的这种作用。当对经CPZ孵育的中性粒细胞进行趋化反应性测试前进行洗涤时，趋化作用的抑制是可逆的。CPZ不仅影响中性粒细胞功能，还影响免疫反应的其他方面。