氯丙嗪对念珠菌属的抑制作用。
Inhibitory effects of chlorpromazine on Candida species.
作者信息
Wood N C, Nugent K M
出版信息
Antimicrob Agents Chemother. 1985 May;27(5):692-4. doi: 10.1128/AAC.27.5.692.
Abstract
Chlorpromazine was tested for antifungal activity by using Candida albicans and standard assays. The MIC of chlorpromazine was 35 micrograms/ml; the minimal fungicidal concentration was also 35 micrograms/ml. The minimal effective concentration was 2.2 to 3.5 micrograms/ml (using assays based on quantitative cultures and growth). There was a slight positive interaction between chlorpromazine and amphotericin B but no interaction between chlorpromazine and rifampin. Chlorpromazine also inhibited C. krusei, C. parapsilosis, C. tropicalis, and Torulopsis glabrata. We conclude that phenothiazines have direct anti-Candida activity and that these drugs appear to have a broad antimicrobial spectrum.
摘要
采用白色念珠菌和标准检测方法对氯丙嗪的抗真菌活性进行了检测。氯丙嗪的最低抑菌浓度为35微克/毫升；最低杀菌浓度也为35微克/毫升。最低有效浓度为2.2至3.5微克/毫升（采用基于定量培养和生长的检测方法）。氯丙嗪与两性霉素B之间存在轻微的正相互作用，但氯丙嗪与利福平之间无相互作用。氯丙嗪还可抑制克鲁斯念珠菌、近平滑念珠菌、热带念珠菌和光滑球拟酵母菌。我们得出结论，吩噻嗪类药物具有直接的抗念珠菌活性，且这些药物似乎具有广泛的抗菌谱。
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