Shimura M, Wada H, Nakasaki T, Hiyoyama K, Mori Y, Nishikawa M, Deguchi H, Deguchi K, Gabazza E C, Shiku H
Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Japan.
Am J Hematol. 1999 Feb;60(2):94-8. doi: 10.1002/(sici)1096-8652(199902)60:2<94::aid-ajh2>3.0.co;2-a.
To evaluate that the relationship between the truncated form of tissue factor pathway inhibitor (TFPI) and the stage of disseminated intravascular coagulation (DIC), we measured the plasma levels of tissue factor (TF) antigen and the intact and truncated forms of TFPI antigens in 41 patients with DIC, 12 with pre-DIC, and 20 with non-DIC. The plasma TF and total TFPI antigen levels were significantly higher in patients with DIC than in non-DIC patients. Plasma levels of intact TFPI antigen in the pre-DIC groups were significantly lower than in the non-DIC and DIC groups. The truncated form of TFPI antigen levels in DIC patients were significantly increased compared with those in non-DIC and pre-DIC patients. The fact that the intact form of TFPI was decreased in pre-DIC patients compared with that in non-DIC patients, suggests that it is consumed in the pre-DIC state and that hypercoagulability occurs in pre-DIC patients. The increased level of the truncated form of TFPI in DIC patients may be attributed to proteolysis of the intact form of TFPI in these patients. The increased level of the truncated form of TFPI may be a useful index for the diagnosis of DIC.
为评估组织因子途径抑制物（TFPI）的截短形式与弥散性血管内凝血（DIC）分期之间的关系，我们检测了41例DIC患者、12例DIC前期患者和20例非DIC患者血浆中组织因子（TF）抗原水平以及TFPI抗原的完整形式和截短形式。DIC患者的血浆TF和总TFPI抗原水平显著高于非DIC患者。DIC前期组的完整TFPI抗原血浆水平显著低于非DIC组和DIC组。与非DIC和DIC前期患者相比，DIC患者的TFPI抗原截短形式水平显著升高。与非DIC患者相比，DIC前期患者中TFPI完整形式降低，这一事实表明其在DIC前期状态下被消耗，且DIC前期患者发生了高凝状态。DIC患者中TFPI截短形式水平升高可能归因于这些患者中TFPI完整形式的蛋白水解。TFPI截短形式水平升高可能是诊断DIC的一个有用指标。
