Wood R I
Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
Ann N Y Acad Sci. 1998 Nov 30;855:362-72. doi: 10.1111/j.1749-6632.1998.tb10594.x.
Mating in the male Syrian hamster requires the interaction of chemosensory and hormonal stimuli. Chemosensory cues from the vomeronasal organ and olfactory mucosa are transmitted through limbic nuclei that contain receptors for gonadal steroid hormones, including the medial amygdaloid nucleus (Me) and medial preoptic area (MPOA). This pathway is essential for mating, as lesions that interrupt transmission of chemosensory cues to MPOA will abolish copulation. Likewise, gonadal steroids facilitate sexual behavior through Me and MPOA, as demonstrated using intracranial implants in the brains of castrate males. In addition, odor and hormonal signals must be integrated in the brain for copulation to occur. Mating is prevented when olfactory bulbectomy is performed ipsilateral to an intracranial testosterone implant, thereby preventing the interaction of odors and hormones. According to our current model, hormones may act as a gating signal to strengthen synaptic contacts along the chemosensory pathway, thereby permitting or enhancing transmission of chemosensory cues.
雄性叙利亚仓鼠的交配需要化学感应刺激和激素刺激的相互作用。来自犁鼻器和嗅觉黏膜的化学感应线索通过边缘核传递，这些边缘核含有性腺甾体激素的受体，包括内侧杏仁核（Me）和内侧视前区（MPOA）。这条通路对交配至关重要，因为中断化学感应线索向MPOA传递的损伤会使交配行为消失。同样，性腺甾体激素通过Me和MPOA促进性行为，这已通过对去势雄性大鼠脑内植入物的实验得到证实。此外，气味和激素信号必须在大脑中整合才能发生交配行为。当在颅内睾酮植入物同侧进行嗅球切除时，交配行为会受到抑制，从而阻止气味和激素的相互作用。根据我们目前的模型，激素可能作为一种门控信号，加强沿化学感应通路的突触联系，从而允许或增强化学感应线索的传递。
