Mulcahy J J, Farrow G M, Furlow W L, Leary F J
Invest Urol. 1976 Nov;14(3):177-81.
Instillation of cytotoxic compounds into the bladder elicits an effect that is based on contact of the agent with the mucosal cells. In the female dog, the distribution of this contact is characteristically in the lower portion of the bladder, and the dome of the bladder is almost invariably spared. Study with formalin indicates that the amount of mucosal contact is best increased by distention of the bladder to full capacity. These findings have significance in the use of topically active agents for the treatment of bladder cancer.
将细胞毒性化合物注入膀胱会引发一种基于药物与黏膜细胞接触的效应。在雌性犬中，这种接触的分布特征性地位于膀胱下部，而膀胱顶部几乎总是未受影响。用福尔马林进行的研究表明，通过将膀胱扩张至最大容量，黏膜接触量能得到最佳增加。这些发现对于使用局部活性药物治疗膀胱癌具有重要意义。
