Olsen T W, Frayer W C, Myers F L, Davis M D, Albert D M
Department of Ophthalmology, University of Wisconsin, Madison, USA.
Arch Ophthalmol. 1999 Jan;117(1):50-4. doi: 10.1001/archopht.117.1.50.
To present and discuss 2 patients with acquired peripapillary pigmented lesions.
We reviewed the patients' clinical records and histopathologic findings.
The first patient was diagnosed with a pigmented papillary lesion that was followed up for 38 years. The second patient was a child with neurofibromatosis type 1 who developed a pigmented peripapillary lesion following excision of an optic nerve glioma. Histologic findings in both cases demonstrated hyperplasia of the retinal pigment epithelium with associated findings.
The lesions presented an idiopathic reactive hyperplasia of the retinal pigment epithelium. The clinical and histopathologic findings resemble findings reported with the combined hamartoma. We suggest that such lesions are reactive in nature, rather than hamartomatous.
介绍并讨论2例获得性视乳头周围色素沉着病变患者。
我们回顾了患者的临床记录和组织病理学检查结果。
首例患者被诊断为色素性乳头病变，随访38年。第二例患者是一名1型神经纤维瘤病患儿，在视神经胶质瘤切除术后出现视乳头周围色素沉着病变。两例的组织学检查结果均显示视网膜色素上皮增生及相关表现。
这些病变表现为视网膜色素上皮的特发性反应性增生。临床和组织病理学检查结果与合并性错构瘤报道的结果相似。我们认为此类病变本质上是反应性的，而非错构瘤性的。
