Pratt R E, Dzau V J
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.02115, USA.
Hypertension. 1999 Jan;33(1 Pt 2):238-47. doi: 10.1161/01.hyp.33.1.238.
We are at the beginning of a biological revolution, spurred on by the Human Genome Project and associated studies. Within the next few years, expressed sequence tags (ESTs) representing all sequences expressed in humans will be determined and their genomic positions will be defined (STSs). The discovery of all the variants in the human genome that contribute to the genetic diversity of the human population will result in the construction of dense polymorphic maps. The rapid growth of the EST, STS, and single-nucleotide polymorphism (SNP) databases, coupled with impressive technological advances, will surely have a dramatic effect on biomedical research. In this review, we will examine the recent advances in genetics and genomics and place these within the context of medical research and patient care, with an emphasis on studies in the cardiovascular system.
我们正处于一场由人类基因组计划及相关研究推动的生物学革命的开端。在未来几年内，代表人类所有表达序列的表达序列标签（EST）将被确定，其基因组位置也将被明确（序列标签位点，STS）。人类基因组中所有导致人群遗传多样性的变异的发现，将促成高密度多态性图谱的构建。EST、STS和单核苷酸多态性（SNP）数据库的迅速增长，再加上令人瞩目的技术进步，必将对生物医学研究产生巨大影响。在这篇综述中，我们将审视遗传学和基因组学的最新进展，并将其置于医学研究和患者护理的背景下进行探讨，重点关注心血管系统方面的研究。
