Jiang W G
Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF4 4XN, The United Kingdom.
J Hepatobiliary Pancreat Surg. 1998;5(4):375-82. doi: 10.1007/s005340050061.
Metastasis is the most life-threatening event in patients with cancer, with the liver being one of the most frequently affected organs. In the development and establishment of metastasis, blood-borne cancer cells utilise various cell adhesion mechanisms (cell-cell, cell matrix, tumour-endothelial and hepatocyte). Thus, cell adhesion molecules have a pivotal role in this process of metastasis formation. This article discusses recent progress in the biology of cell adhesion molecules in the formation of liver metastasis and the clinical implications of the findings.
转移是癌症患者最危及生命的事件，肝脏是最常受影响的器官之一。在转移的发生和形成过程中，血行癌细胞利用多种细胞黏附机制（细胞-细胞、细胞-基质、肿瘤-内皮细胞和肝细胞）。因此，细胞黏附分子在转移形成过程中起关键作用。本文讨论了细胞黏附分子生物学在肝转移形成中的最新进展以及这些发现的临床意义。
