Goldman M D, Grimby G, Mead J
J Appl Physiol. 1976 Nov;41(5 Pt. 1):752-63. doi: 10.1152/jappl.1976.41.5.752.
Estimates of the mechanical work of breathing derived from measurements of separate rib cage and abdominal volume displacements, each plotted against transthoracic pressure, include the elastic cost of chest wall distortion which may occur during breathing. Inspiratory work is partitioned between the diaphragm and the rib cage musculature by adding measurements of transabdominal pressure. The mechanical work of breathing derived from separate rib cage and abdominal volume-pressure (V-P) tracings (the sum of work done by the diaphragm, rib cage, and abdominal musculature) is compared with ventilatory work estimated from the Campbell diagram (which does not include any distortional work). During resting breathing the two estimates are closely comparable, consistent with little or no distortion of the chest wall during quiet breathing. As ventilation increases, the estimate developed from rib cage and abdominal tracings reveals systematically greater mechanical work than is estimated from the Campbell diagram, consistent with distortion of the chest wall from the relaxed thoracoabdominal configuration at higher levels of ventilation. At ventilations achieved during exercise, the Campbell diagram may underestimate the work of breathing by up to 25%.
通过测量单独的胸廓和腹部容积位移，并将其分别与跨胸压绘制而成的呼吸机械功估计值，包括了呼吸过程中可能发生的胸壁变形的弹性成本。通过添加经腹压测量值，吸气功在膈肌和胸廓肌肉组织之间进行分配。将由单独的胸廓和腹部容积-压力（V-P）曲线得出的呼吸机械功（膈肌、胸廓和腹部肌肉组织所做功的总和）与根据坎贝尔图估计的通气功（不包括任何变形功）进行比较。在静息呼吸期间，这两种估计值非常接近，这与安静呼吸时胸壁几乎没有或没有变形是一致的。随着通气量增加，由胸廓和腹部曲线得出的估计值显示出系统性地比根据坎贝尔图估计的机械功更大，这与在较高通气水平下胸壁从松弛的胸腹构型发生变形是一致的。在运动时达到的通气量下，坎贝尔图可能会低估呼吸功达25%。
