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[阿昔洛韦治疗——其对疱疹性角膜炎视力及复发率的影响]

[Acyclovir treatment--its effect on visual acuity and the rate of recurrences in herpetic keratitis].

作者信息

Corina P

机构信息

Clinica Oftalmologică Venizelios-Iraklio, Grecia.

出版信息

Oftalmologia. 1998;42(2):37-41.

PMID:9932353
Abstract

We treated a number of 141 patients suffering of herpetic keratitis--34 were treated with Acyclovir in the first 72 hours the symptoms started, 42 were treated with Acyclovir after this interval and 65 were treated with IDU. We compared visual acuity after six month and we proved that those that were treated with Acyclovir had the same or better visual performances in most cases. Recurrence rate was 0% in the first year and 2.94% in the second year for those witch were treated with Acyclovir in the first 72 hours symptoms started and 2.94% in the first year and 14.71% in the second year for those treated with Acyclovir after this interval. Patients treated with IDU had suffered 23.53% recurrences in the first year and 41.18% recurrences in the second year. Acyclovir treatment and its precociousness protect patients sight and reduce number of recurrences.

摘要

我们治疗了141例疱疹性角膜炎患者,其中34例在症状出现后的头72小时内接受了阿昔洛韦治疗,42例在此间隔后接受了阿昔洛韦治疗,65例接受了碘苷治疗。我们比较了六个月后的视力,结果证明,在大多数情况下,接受阿昔洛韦治疗的患者视力相同或更好。在症状出现后的头72小时内接受阿昔洛韦治疗的患者,第一年复发率为0%,第二年为2.94%;在此间隔后接受阿昔洛韦治疗的患者,第一年复发率为2.94%,第二年为14.71%。接受碘苷治疗的患者第一年复发率为23.53%,第二年为41.18%。阿昔洛韦治疗及其早期应用可保护患者视力并减少复发次数。

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