Schwinn G, Schwarck H, McIntosh C, Milstrey H R, Willms B, Köbberling J
J Clin Endocrinol Metab. 1976 Nov;43(5):1183-5. doi: 10.1210/jcem-43-5-1183.
Pimozide, a specific blocker of dopamine receptors, was administered orally to 10 diabetics for 2 days before an arginine-hydrochloride infusion. In 8 healthy volunteers and 20 diabetics exercise tests on a bicycle ergometer were performed with a load of 100 Watts and 50 Watts respectively without or after a single dose of pimozide 30 min before the test. In 4 male diabetics day profiles of growth hormone (GH) were estimated without and during treatment with pimozide for 4 days. The arginine and exercise induced GH release was found to be significantly lowered by pimozide, whereas the marked spontaneous fluctuations in the diabetics were even enhanced by pimozide. These data support the concept of the involvement of dopaminergic stimulation in the response of GH to arginine and exercise. The spontaneous fluctuations of GH, however, seem to be regulated by other neuroendocrine mechanisms.
匹莫齐特是一种多巴胺受体特异性阻断剂，在给10名糖尿病患者静脉输注精氨酸-盐酸盐前两天，让他们口服该药。对8名健康志愿者和20名糖尿病患者分别在负荷为100瓦和50瓦的自行车测力计上进行运动测试，测试前30分钟未服用或服用单剂量匹莫齐特。对4名男性糖尿病患者评估了生长激素（GH）在未治疗和匹莫齐特治疗4天期间的日变化情况。发现匹莫齐特可显著降低精氨酸和运动诱导的GH释放，而糖尿病患者明显的自发波动甚至因匹莫齐特而增强。这些数据支持多巴胺能刺激参与GH对精氨酸和运动反应的观点。然而，GH的自发波动似乎受其他神经内分泌机制调节。
