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多巴胺能阻断对人体生长激素和催乳素分泌的影响。

Effect of dopaminergic blockade on the secretion of growth hormone and prolactin in man.

作者信息

Masala A, Delitala G, Alagna S, Devilla L, Rovasio P P, Lotti G

出版信息

Metabolism. 1978 Aug;27(8):921-6. doi: 10.1016/0026-0495(78)90135-x.

DOI:10.1016/0026-0495(78)90135-x
PMID:672613
Abstract

Serum growth hormone (GH) response to insulin and glucagon administration was studied in 12 male and 12 female volunteers under control conditions, and under treatment with pimozide and metoclopramide. In addition, serum prolactin levels were measured during the treatment period. Pimozide and metoclopramide administration had no effect on the GH response to insulin and glucagon. In contrast, serum prolactin levels increased markedly during the treatment period. Dopaminergic blockade is unable to affect GH secretion in response to insulin and glucagon administration in man.

摘要

在对照条件下以及使用匹莫齐特和甲氧氯普胺治疗期间,对12名男性和12名女性志愿者给予胰岛素和胰高血糖素后血清生长激素(GH)反应进行了研究。此外,在治疗期间测量了血清催乳素水平。给予匹莫齐特和甲氧氯普胺对GH对胰岛素和胰高血糖素的反应没有影响。相比之下,治疗期间血清催乳素水平显著升高。多巴胺能阻断无法影响人体对胰岛素和胰高血糖素给药的GH分泌。

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2
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引用本文的文献

1
Prolactin response to exercise, metoclopramide and other provacative agents in children.儿童体内催乳素对运动、甲氧氯普胺及其他刺激剂的反应。
Eur J Pediatr. 1980 Sep;134(3):231-7. doi: 10.1007/BF00441478.
2
Metoclopramide. An updated review of its pharmacological properties and clinical use.甲氧氯普胺。对其药理特性及临床应用的最新综述。
Drugs. 1983 May;25(5):451-94. doi: 10.2165/00003495-198325050-00002.
3
Metoclopramide-induced reversible impotence.甲氧氯普胺引起的可逆性阳痿。
West J Med. 1986 Mar;144(3):359-61.