β-羟基丁酸诱导淋巴细胞受体对胰岛素的结合增加。

Increased insulin binding by lymphocyte receptors induced by beta-OH butyrate.

作者信息

Merimee T J, Pulkkinen A J, Lofton S

出版信息

J Clin Endocrinol Metab. 1976 Nov;43(5):1190-2. doi: 10.1210/jcem-43-5-1190.

Abstract

The serum concentration of ketones increases in both fasting and diabetic ketoacidosis. Whether ketones alter, independent of changes in pH, in number and affinity of insulin receptors is not known. The binding of insulin 125I by 24 X 10(6)IM-9 lymphocyte cells was examined in both the presence and absence of 8 mM beta-OH butyrate. Studies were conducted at multiple concentrations of insulin. A consistent increase of insulin binding was induced by beta-OH butyrate. The mean maximum increase of insulin binding was 35%, which achieved significance at the 1% level.

摘要

在禁食和糖尿病酮症酸中毒状态下，血清酮浓度均会升高。目前尚不清楚酮是否会独立于pH值变化之外，改变胰岛素受体的数量和亲和力。在存在和不存在8 mM β-羟基丁酸的情况下，检测了24×10⁶个IM-9淋巴细胞对¹²⁵I胰岛素的结合情况。研究在多种胰岛素浓度下进行。β-羟基丁酸可诱导胰岛素结合持续增加。胰岛素结合的平均最大增幅为35%，在1%水平上具有统计学意义。