5-羟色胺效应与紫贻贝软体动物平滑肌（ABRM）舒张的调控
5-HT effect and the control of the relaxation of a molluscan smooth muscle (ABRM) of Mytilus edulis L.
作者信息
Gilloteaux J
出版信息
Cytobiologie. 1978 Jun;17(1):94-106.
Morphological differences exist between the arrangement of myofilaments in relaxed EDTA-treated fibres (induced by a 10(-9)M Ca2+ solution, ionic strength 0.28 at pH7.0) and the fibres relaxed by 5-HT added into the same relaxing solution. Complemented by a tension recording of an ABRM preparation, we find the following characteristics during 5-HT relaxation: (i) The distance between centers of thick neighboring filaments is increased. (ii) The thin filaments appear loosely dispersed between the thick ones. These observations suggest that decrease in myofilament interactions is responsible for the plasticizing effects of 5-HT. The sarcolemma appears with some granularity after 5-HT treatment; nexuses and dyads, however, are well defined.
在经乙二胺四乙酸（EDTA）处理的松弛纤维（由10⁻⁹M钙离子溶液诱导，pH值为7.0时离子强度为0.28）中肌丝的排列与在相同松弛溶液中添加5-羟色胺（5-HT）后松弛的纤维之间存在形态学差异。通过对两栖类骨骼肌（ABRM）标本的张力记录补充，我们在5-HT松弛过程中发现以下特征：（i）相邻粗肌丝中心之间的距离增加。（ii）细肌丝似乎松散地分散在粗肌丝之间。这些观察结果表明，肌丝相互作用的减少是5-HT产生增塑作用的原因。5-HT处理后肌膜出现一些颗粒状；然而，连接复合体和二联体定义明确。
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