Moomjy M, Cholst I, Mangieri R, Rosenwaks Z
Center For Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, The New York Hospital-Cornell Medical Center, New York 10021, USA.
Fertil Steril. 1999 Jan;71(1):15-21. doi: 10.1016/s0015-0282(98)00420-8.
To ascertain whether obstetric, gynecologic, or congenital variables affect implantation efficiency or eventual delivery in donor oocyte recipients.
Clinical study.
Academic tertiary care infertility clinic.
PATIENT(S): A total of 370 recipients.
INTERVENTION(S): Fresh ET following oocyte donation in a hormone replacement cycle.
MAIN OUTCOME MEASURE(S): Regression analyses were performed to detect any statistically significant difference in the pregnancy rate (PR), delivery rate, miscarriage rate, or implantation rate associated with different obstetric, gynecologic, and congenital independent variables while accounting for the age of the recipient in each analysis.
RESULT(S): For all recipients, a clinical PR per transfer of 58.9% was achieved, with an implantation rate of 30%. A significant decline in the implantation rate was noted in relation to increasing age of the recipient. A history of tubal disease was associated with a significantly lower implantation rate and a significantly lower ongoing and delivered PR. Asherman's syndrome, despite surgical correction, appeared to negatively affect the ongoing and delivered PR.
CONCLUSION(S): With the exceptions of recipient age and a history of tubal disease, all other uterine factors studied did not appear to influence the implantation potential of an embryo resulting from oocyte donation. A history of tubal disease had a distinctly negative effect on implantation efficiency and delivery potential for a given recipient. This finding highlights the need to identify the mechanisms underlying the negative effect of tubal disease so that donor oocyte recipients and all other patients with this cause of infertility can benefit from directed therapy.
确定产科、妇科或先天性因素是否会影响供卵受者的着床效率或最终分娩情况。
临床研究。
学术性三级护理不孕症诊所。
共370名受者。
在激素替代周期中进行卵母细胞捐赠后的新鲜胚胎移植。
进行回归分析，以检测与不同产科、妇科和先天性自变量相关的妊娠率（PR）、分娩率、流产率或着床率的任何统计学显著差异，同时在每次分析中考虑受者的年龄。
所有受者每次移植的临床妊娠率为58.9%，着床率为30%。着床率随受者年龄增加而显著下降。输卵管疾病史与显著较低的着床率以及显著较低的持续妊娠率和分娩率相关。阿谢曼综合征尽管经过手术矫正，但似乎对持续妊娠率和分娩率有负面影响。
除受者年龄和输卵管疾病史外，所研究的所有其他子宫因素似乎均未影响卵母细胞捐赠产生的胚胎的着床潜力。输卵管疾病史对特定受者的着床效率和分娩潜力有明显的负面影响。这一发现凸显了确定输卵管疾病负面影响背后机制的必要性，以便供卵受者和所有其他因该原因导致不孕的患者能够从针对性治疗中获益。
