Reisser C, Eichhorn K, Herold-Mende C, Born A I, Bannasch P
Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Germany.
Int J Cancer. 1999 Jan 18;80(2):194-8. doi: 10.1002/(sici)1097-0215(19990118)80:2<194::aid-ijc6>3.0.co;2-m.
Positron emission tomography studies on malignant head and neck tumors have shown that tumor growth and elevated glucose uptake are associated. On a molecular level, glucose uptake is mediated by specific glucose transport proteins, which exhibit an altered expression in head and neck malignant neoplasms. However, it is unknown when during development of squamous cell carcinomas an alteration of the expression of glucose transport proteins occurs. We have studied the expression of different facilitating glucose transport proteins (GLUT 1, 2, 3 and 4) by immunohistochemistry in a variety of preneoplastic and neoplastic mucosal lesions of the head and neck. We have observed weak expression of GLUT 1 in normal mucosa, a marked expression of GLUT 1 throughout preneoplastic lesions, which correlated well with the degree of dysplasia. In squamous cell carcinomas of the head and neck (HNSCC) and metastases, GLUT 1 was always expressed strongly. In contrast, GLUT 2, 3 and 4 were not detected in any of the epithelial tissues examined. The increased expression of GLUT 1 in dysplastic lesions and its sustained expression in SCC indicate that changes of GLUT 1 expression are early events during development of HNSCC. Therefore, the detection of GLUT 1 might be a reliable marker in the diagnosis of premalignant lesions of the oropharyngeal mucosa.
正电子发射断层扫描研究显示，头颈部恶性肿瘤的肿瘤生长与葡萄糖摄取增加有关。在分子水平上，葡萄糖摄取由特定的葡萄糖转运蛋白介导，这些蛋白在头颈部恶性肿瘤中表达改变。然而，鳞状细胞癌发生过程中葡萄糖转运蛋白表达改变的时间尚不清楚。我们通过免疫组织化学研究了不同的易化葡萄糖转运蛋白（GLUT 1、2、3和4）在头颈部多种癌前和肿瘤性黏膜病变中的表达。我们观察到，GLUT 1在正常黏膜中表达较弱，在整个癌前病变中GLUT 1表达明显，且与发育异常程度密切相关。在头颈部鳞状细胞癌（HNSCC）及其转移灶中，GLUT 1总是强烈表达。相比之下，在所检查的任何上皮组织中均未检测到GLUT 2、3和4。GLUT 1在发育异常病变中的表达增加及其在鳞状细胞癌中的持续表达表明，GLUT 1表达变化是HNSCC发生过程中的早期事件。因此，检测GLUT 1可能是诊断口咽黏膜癌前病变的可靠标志物。
