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家兔下丘脑电刺激诱导脂肪分解的机制

Mechanism of lipolysis induced by electrical stimulation of the hypothalamus in the rabbit.

作者信息

Kumon A, Takahashi A, Hara T, Shimazu T

出版信息

J Lipid Res. 1976 Nov;17(6):551-8.

PMID:993668
Abstract

Electrical stimulation of the ventro-medial hypothalamus of the rabbit elevated plasma glycerol concentration. This elevation was suppressed by treatments of the animals with hexamethonium and propranolol, or by adrenalectomy, but was not suppressed by treatments with atropine and phentolamine. These results would indicate that the effect of electrical stimulation of ventro-medial hypothalamus is mainly mediated by catecholamine(s) liberated from the adrenal medulla and acts on beta-receptor of adipose tissue.

摘要

电刺激家兔腹内侧下丘脑可提高血浆甘油浓度。六甲铵和普萘洛尔处理动物、或肾上腺切除可抑制这种升高,但阿托品和酚妥拉明处理则不能抑制。这些结果表明,电刺激腹内侧下丘脑的作用主要由肾上腺髓质释放的儿茶酚胺介导,并作用于脂肪组织的β受体。

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