de Rouffignac C, Monnens L
J Physiol. 1976 Oct;262(1):119-29. doi: 10.1113/jphysiol.1976.sp011588.
The development of single nephron glomerular filtration rate (SNGFER) was studied in both superficial and juxtamedullary nephrons in rats in relation to concomitant morphologic maturation. These experiments were carried out in rats between 23 and 91 days of age (between 36 nad 275 g body weight) with the [14C]ferrocyanide infusion technique. 2. SNGFR of the superficial and juxtamedullary nephrons increased with body weight, glomerular volume and proximal tubular length. 3. The ratio SNGFR of the superficial (S) nephrons/SNGFR of the juxtamedullary (JM) nephrons rose from 0-60 in the 40-60 g rats to 0-84 in the adult rats, demonstrating the centrifugal functional maturation of the nephrons. 4. The S/JM ratio for both glomerular volume and tubular length was constant and averaged 0-72+/--0-12 and 0-81+/-0-05, respectively, indicating that while the increase in SNGFR was greater for S than for JM nephrons, this was not accompanied by concomitant disproportionate increases of glomerular volume and/or proximal tubular length between these nephron categories during development in the rat.
在大鼠中，研究了浅表肾单位和近髓肾单位的单肾单位肾小球滤过率（SNGFER）的发育与伴随的形态学成熟之间的关系。这些实验是在23至91日龄（体重36至275克）的大鼠中采用[14C]亚铁氰化物注入技术进行的。2. 浅表肾单位和近髓肾单位的SNGFR随体重、肾小球体积和近端肾小管长度的增加而增加。3. 浅表（S）肾单位的SNGFR/近髓（JM）肾单位的SNGFR比值在40至60克的大鼠中从0.60升至成年大鼠中的0.84，表明肾单位的离心性功能成熟。4. 肾小球体积和肾小管长度的S/JM比值恒定，分别平均为0.72±0.12和0.81±0.05，这表明虽然S肾单位的SNGFR增加幅度大于JM肾单位，但在大鼠发育过程中，这些肾单位类别之间的肾小球体积和/或近端肾小管长度并未伴随不成比例的增加。
