Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Clin Transl Med. 2013 May 21;2(1):11. doi: 10.1186/2001-1326-2-11.
The kidney has key roles in maintaining human health. There is an escalating medical crisis in nephrology as growing numbers of patients suffer from kidney diseases that culminate in organ failure. While dialysis and transplantation provide life-saving treatments, these therapies are rife with limitations and place significant burdens on patients and healthcare systems. It has become imperative to find alternative ways to treat existing kidney conditions and preemptive means to stave off renal dysfunction. The creation of innovative medical approaches that utilize stem cells has received growing research attention. In this review, we discuss the regenerative and maladaptive cellular responses that occur during acute and chronic kidney disease, the emerging evidence about renal stem cells, and some of the issues that lie ahead in bridging the gap between basic stem cell biology and regenerative medicine for the kidney.
肾脏在维护人体健康方面起着关键作用。肾病学领域正面临着日益严重的医疗危机，越来越多的患者患有肾脏疾病，最终导致器官衰竭。虽然透析和移植提供了救生治疗，但这些疗法存在诸多限制，给患者和医疗系统带来了巨大负担。因此，寻找治疗现有肾脏疾病的替代方法和预防肾功能障碍的先发手段已变得至关重要。利用干细胞创造创新的医疗方法受到了越来越多的研究关注。在这篇综述中，我们讨论了急性和慢性肾脏疾病期间发生的再生和适应性细胞反应、肾脏干细胞的新出现证据，以及在将基础干细胞生物学和肾脏再生医学之间的差距弥合方面所面临的一些问题。
