Dykhuizen D, Hartl D
J Bacteriol. 1978 Sep;135(3):876-82. doi: 10.1128/jb.135.3.876-882.1978.
Lactose killing is a peculiar phenomenon in which 80 to 98% of the Escherichia coli cells taken from a lactose-limited chemostat die when plated on standard lactose minimal media. This unique form of suicide is caused by the action of the lactose permease. Since uptake of either lactose or galactose by the lactose permease caused death, the action of rapid transport across the membrane must be the cause of the phenomenon. Alternative causes of lactose killing, such as accumulation of toxic metabolic intermediates or action of the beta-galactosidase, have been eliminated. It is proposed that rapid uptake of sugars by the lactose permease disrupts membrane function, perhaps causing collapse of the membrane potential.
乳糖杀伤是一种特殊现象，即从乳糖限制恒化器中取出的80%至98%的大肠杆菌细胞接种到标准乳糖基本培养基上时会死亡。这种独特的自杀形式是由乳糖通透酶的作用引起的。由于乳糖通透酶对乳糖或半乳糖的摄取都会导致细胞死亡，因此跨膜快速转运的作用必定是该现象的原因。乳糖杀伤的其他原因，如有毒代谢中间体的积累或β-半乳糖苷酶的作用，已被排除。有人提出，乳糖通透酶对糖的快速摄取会破坏膜功能，可能导致膜电位崩溃。
