Kabara J J, Holzschu D L, Catsoulacos D P
Lipids. 1976 Oct;11(10):755-62. doi: 10.1007/BF02533051.
Thirty-nine nitrogen-containing steroids were tested against two gram-negative, five gram-positive, and two yeast organisms. Many of these steroids have been previously reported to inhibit various metabolic processes involving sterol metabolism. While low minimal inhibitory concentration (MIC) values were recorded for sterol producing yeast, growth of bacteria which contain no sterols was also inhibited. Structure-function studies provided no relationship between biological activity and hypocholesteremic effects of these azasteroids. A hypothesis put forward is that amino and azasteroids are effectors of membrane which, in the case of mitochondria, lead to changes in adenosine triphosphate levels and/or dehydrogenase activity. Their effects on sterol metabolism, therefore, may be of secondary consideration.
对39种含氮甾体化合物进行了针对两种革兰氏阴性菌、五种革兰氏阳性菌和两种酵母微生物的测试。此前已有报道称，其中许多甾体化合物可抑制涉及甾醇代谢的各种代谢过程。虽然记录到产甾醇酵母的最低抑菌浓度（MIC）值较低，但不含甾醇的细菌生长也受到了抑制。结构-功能研究未发现这些氮杂甾体化合物的生物活性与降胆固醇作用之间存在关联。提出的一个假设是，氨基甾体化合物和氮杂甾体化合物是膜的效应物，就线粒体而言，会导致三磷酸腺苷水平和/或脱氢酶活性发生变化。因此，它们对甾醇代谢的影响可能是次要的。
