Davies J
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Novartis Found Symp. 1998;217:195-205; discussion 205-8.
Multiple drug resistance in mycobacteria compromises the use of antibiotics. Although the genetic and biochemical bases of antibiotic resistance in mycobacteria are largely understood, a number of questions remain to be addressed. This chapter discusses the potential roles of hypermutability and compensatory mutations in establishing stable resistant phenotypes in the pathogenic mycobacteria.
分枝杆菌中的多重耐药性会影响抗生素的使用。尽管分枝杆菌抗生素耐药性的遗传和生化基础已基本明确，但仍有一些问题有待解决。本章讨论了高突变性和补偿性突变在致病性分枝杆菌中建立稳定耐药表型方面的潜在作用。
