Gupta J M, Starr H, Fincher P, Lam-Po-Tang P R
Med J Aust. 1976 Aug 28;2(9):338-40.
Coagulation studies were performed on 128 babies who were premature or who had respiratory distress syndrome (RDS). Forty-four babies were found to have abnormal coagulation parameters. Twenty-one were treated with plasma coagulation factors II, VII, IX and X (PPSB), and of these six died from intraventricular haemorrhage (IVH). Twenty-two did not have PPSB treatment and four died from IVH. In 84 babies in whom coagulation studies gave normal results only one baby died from IVH. The combination of RDS and abnormal coagulation produced a high-risk group to IVH and treatment with PPSB did not reduce the incidence of IVH. It is postulated that prevention of IVH lies in early and effective treatment of RDS.
对128名早产或患有呼吸窘迫综合征（RDS）的婴儿进行了凝血研究。发现44名婴儿的凝血参数异常。21名婴儿接受了血浆凝血因子II、VII、IX和X（PPSB）治疗，其中6名死于脑室内出血（IVH）。22名未接受PPSB治疗的婴儿中有4名死于IVH。在凝血研究结果正常的84名婴儿中，只有1名死于IVH。RDS和异常凝血的组合产生了IVH的高危组，PPSB治疗并未降低IVH的发生率。据推测，IVH的预防在于对RDS进行早期和有效的治疗。
