Amagasaki K, Yamazaki H, Ohmori K, Koizumi H, Hashizume K, Sasaguchi N
Department of Neurosurgery, Yamanashi Prefectural Central Hospital, Kofu, Japan.
J Neurosurg. 1999 Feb;90(2):355-8. doi: 10.3171/jns.1999.90.2.0355.
This 55-year-old man presented with malignant intravascular lymphomatosis, a rare vascular disorder of the central nervous system characterized by proliferation of malignant lymphoma cells. The clinical manifestations were focal neurological signs and progressive dementia. Angiography demonstrated stenoses of the cortical veins. Postmortem examination revealed infiltration of tumor cells into the lumen and vascular wall, although the stenoses were caused primarily by fibrin thrombi. To the authors' knowledge this is the first case of malignant intravascular lymphomatosis associated with venous stenosis.
这位55岁男性患有恶性血管内淋巴瘤，这是一种罕见的中枢神经系统血管疾病，其特征为恶性淋巴瘤细胞增殖。临床表现为局灶性神经体征和进行性痴呆。血管造影显示皮质静脉狭窄。尸检发现肿瘤细胞浸润至管腔和血管壁，尽管狭窄主要由纤维蛋白血栓引起。据作者所知，这是首例与静脉狭窄相关的恶性血管内淋巴瘤病例。
