Bücherl E S
Med Prog Technol. 1976 Jul 20;4(1-2):61-70.
The state of the art in the development of artificial heart research based on more than 100 own animal experiments and information from the other groups working in the same field is laid out. Consideration is given to a variety of special problems. The use of biomaterials (blood compatibility and mechanical strength and durability), the flow pattern in the pumps (clot formation), and special hemodynamical effects are discussed as well as different driving systems and percutane energy transmission (avoidance of infection). Respective measurements show the hemodynamics in the systemic and pulmonary circulation, especially the difficulties of the venous inflow and the regulation of the pumps. The effect of an active artificial atrium and new ways of computerized regulation using noninvasively measured parameters are described. Other pathophysiologic findings (lung, kidney, acid-base metabolism, gastrointestinal tract, blood) are dealt with according to their importance. The miniaturization of the driving system and new methods of energy supply necessary for a totally implantable artificial heart system, envisaged for the future, are also pointed out.
基于100多项自主动物实验以及同一领域其他研究团队的信息，阐述了人工心脏研究的发展现状。考虑了各种特殊问题。讨论了生物材料的使用（血液相容性、机械强度和耐久性）、泵内的血流模式（血栓形成）以及特殊血液动力学效应，还讨论了不同的驱动系统和经皮能量传输（避免感染）。相应的测量显示了体循环和肺循环中的血液动力学，特别是静脉流入的困难和泵的调节。描述了主动人工心房的作用以及使用无创测量参数的计算机化调节新方法。根据其重要性处理了其他病理生理学发现（肺、肾、酸碱代谢、胃肠道、血液）。还指出了未来设想的完全可植入人工心脏系统所需的驱动系统小型化和新的能量供应方法。
