Pinilla M, González F M, Górriz C, Arellano B, Vicente J, Trinidad A
Servicio de ORL, Clínica Puerta de Hierro, Universidad Autónoma de Madrid.
Acta Otorrinolaringol Esp. 1998 Nov-Dec;49(8):633-6.
The treatment of early-stage laryngeal cancer using either partial surgical techniques or irradiation still is controversial. The performance of rescue surgical procedures after irradiation is related to increased postsurgical complications and lower survival rates. We made a retrospective study of 73 patients who underwent rescue surgery after failure of radiotherapy in our department in the last 10 years. A statistical analysis was made of the complications and survival rate of these patients in accordance with tumor location and clinicopathological stage compared with patients who underwent surgery alone (n = 435). More rescue surgery was performed for glottic carcinomas (52/73) than for supraglottic carcinomas (21/73). No significant differences were found in the complication rate (23.6%) compared with the control group (19.6%). There was a significant reduction in survival in patients who underwent previous irradiation of supraglottic tumors compared with glottic tumors and the control group. In view of these results, we conclude that irradiation is not a good option as an initial treatment for supraglottic tumors and that the procedure of choice should be surgical.
采用部分手术技术或放射治疗早期喉癌仍存在争议。放射治疗后进行挽救性手术与术后并发症增加及生存率降低有关。我们对过去10年在我科放疗失败后接受挽救性手术的73例患者进行了回顾性研究。根据肿瘤位置和临床病理分期,对这些患者的并发症和生存率与单纯接受手术的患者(n = 435)进行了统计学分析。声门癌(52/73)接受挽救性手术的比例高于声门上癌(21/73)。与对照组(19.6%)相比,并发症发生率(23.6%)无显著差异。与声门肿瘤及对照组相比,先前接受声门上肿瘤放疗的患者生存率显著降低。鉴于这些结果,我们得出结论,放射治疗不是声门上肿瘤初始治疗的理想选择,首选治疗方法应为手术。