Biocina-Lukenda D, Cekić-Arambasin A, Jorgić-Srdjak K
Department of Oral Pathology, School of Dental Medicine, University of Zagreb, Croatia.
Coll Antropol. 1998 Dec;22 Suppl:83-8.
NK-cells are one of main indicators of nonspecific and innate immunity. Disorder of NK-cell functional activity can result with autoimmune diseases and it can suppose that every disorder has significant role in pathogenetic mechanisms in OLR, like oral mucocutaneous autoimmunity disease. Result of NK cells function, like indicator of innate immunity condition, can be very interesting in patients with OLR. Examination of NK-cell functional activity and their total count in peripheral blood of patients were spended, which included 38 patients. Examination of total NK cell count in peripheral blood and their activity spended by method described by Rabatić at al. Results showed statistically significant correlation with control groups in all functional activity, NK cell to target cells, in ratio 25:1, 50:1 and 100:1 (E:T) %l. Statistically significant result of lower NK cells functional activity, and total NK cell count in peripheral blood in patients with OLR, refer to alteration of innate immunity persons with this recurrent oral disease. That disorder can have important role in pathogenetic mechanisms in beginnings of OLR.
自然杀伤细胞（NK 细胞）是非特异性和固有免疫的主要指标之一。NK 细胞功能活性紊乱可导致自身免疫性疾病，并且可以推测，每种紊乱在口腔扁平苔藓（OLR）的发病机制中都具有重要作用，比如口腔黏膜皮肤自身免疫性疾病。作为固有免疫状态指标的 NK 细胞功能结果，对于 OLR 患者可能非常有趣。对 38 例患者外周血中的 NK 细胞功能活性及其总数进行了检测。采用 Rabatić 等人描述的方法对外周血中 NK 细胞的总数及其活性进行检测。结果显示，在所有功能活性方面，NK 细胞与靶细胞比例为 25:1、50:1 和 100:1（E:T）时，与对照组存在统计学显著相关性。OLR 患者外周血中 NK 细胞功能活性降低以及 NK 细胞总数减少的统计学显著结果，表明患有这种复发性口腔疾病的个体固有免疫发生了改变。这种紊乱在 OLR 发病初期的发病机制中可能具有重要作用。
