Charazinska-Carewicz Katarzyna, Ganowicz Ewa, Krol Maria, Gorska Renata
Department of Periodontology and Oral Diseases, Medical University of Warsaw, Warsaw, Poland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Feb;105(2):202-5. doi: 10.1016/j.tripleo.2007.03.031. Epub 2007 Jul 26.
To assess the cellular and humoral immunity in patients with reticular and atrophic-erosive oral lichen planus (OLP).
Lymphocyte phenotype analysis of 50 patients with OLP and 16 control subjects was performed by means of flow cytometry. The results were analyzed by the Mann-Whitney U test.
In the patient group the percentage of naïve helper T cells was significantly decreased, while that of memory cells was increased, resulting in a significantly higher ratio of memory to naïve cells in the OLP group than in the control group. In the group of patients with atrophic-erosive OLP, the percentages of cytotoxic/suppressor T cells and cytotoxic/suppressor naïve T cells were found to be slightly decreased.
The results indicate that the relative ratio of immunocompetent cells in the peripheral blood is altered in patients with lichen planus and that the exact character of these disturbances depends on OLP form. Some of the alterations observed in these patients are typical to autoimmune diseases, thus promoting the concept of autoimmune etiopathogenesis of lichen planus.
评估网状型和萎缩糜烂型口腔扁平苔藓（OLP）患者的细胞免疫和体液免疫。
采用流式细胞术对50例OLP患者和16例对照者进行淋巴细胞表型分析。结果采用曼-惠特尼U检验进行分析。
患者组中初始辅助性T细胞百分比显著降低，而记忆细胞百分比增加，导致OLP组中记忆细胞与初始细胞的比例显著高于对照组。在萎缩糜烂型OLP患者组中，发现细胞毒性/抑制性T细胞和细胞毒性/抑制性初始T细胞的百分比略有降低。
结果表明，扁平苔藓患者外周血中免疫活性细胞的相对比例发生改变，且这些紊乱的确切特征取决于OLP的类型。在这些患者中观察到的一些改变是自身免疫性疾病的典型表现，从而支持了扁平苔藓自身免疫病因学的概念。
