Murillo F J, Cerdá-Olmedo E
Mol Gen Genet. 1976 Oct 18;148(1):19-24. doi: 10.1007/BF00268541.
Three independent mutations of Phycomyces blakesleeanus resulting in overaccumulation of beta-carotene are recessive and belong to the same complementation group. The corresponding gene has been named carS. Evidence is presented that gene carS is not the same as gene carA, previously defined by mutations blocking carotene production. Vitamin A increases carotenogenesis in wild types and in carS mutants to about the same extent. Intersexual heterokaryosis increases carotenogenesis most prominently in carS genetic backgrounds (up to 300 times the production of the wild type in the same conditions). Vitamin A, intersexual heterokaryosis and carS mutations are thought to stimulate carotenogenesis through different mechanisms. It is suggested that the carS gene product participates in end-product regulation of the pathway.
布拉克须霉（Phycomyces blakesleeanus）中导致β-胡萝卜素过度积累的三个独立突变是隐性的，且属于同一互补群。相应的基因已被命名为carS。有证据表明，基因carS与先前由阻断胡萝卜素产生的突变所定义的基因carA不同。维生素A在野生型和carS突变体中对类胡萝卜素生成的促进程度大致相同。两性间异核现象在carS遗传背景下对类胡萝卜素生成的促进最为显著（在相同条件下可达野生型产量的300倍）。维生素A、两性间异核现象和carS突变被认为是通过不同机制刺激类胡萝卜素生成的。有人提出，carS基因产物参与该途径的终产物调节。
