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[胆囊血管平滑肌瘤:透析患者血胆症的罕见病因]

[Angioleiomyoma of the gallbladder: a rare cause of hemobilia in a patient on dialysis].

作者信息

Aschl G, Wallner M, Tuppy H, Fröhler W, Kramar R

机构信息

3. Interne Abteilung, Krankenhauses Barmherzige Schwestern vom Hl. Kreuz, Wels, Osterreich.

出版信息

Dtsch Med Wochenschr. 1999 Jan 8;124(1-2):13-6. doi: 10.1055/s-2008-1062603.

Abstract

HISTORY AND FINDINGS

Acute colicky upper abdominal pain occurred in a 47-year-old man on renal dialysis who also had chronic recurrent pancreatitis. On physical examination he was noted to be slightly jaundiced and he had slight pain when the liver edge was palpated. A few days later melaena developed and the haemoglobin concentration fell from normal levels to 6.9 g/dl.

INVESTIGATIONS

Serology gave no evidence of acute pancreatitis, but biochemical tests indicated cholestasis. Ultrasonography revealed widening of the intra- and extrahepatic biliary tract. Endoscopic retrograde cholecystopancreatography demonstrated bleeding from the biliary tract (haemobilia) as the source of the bleeding. Selective angiography of the coeliac trunk showed extravasation in the region of the gallbladder.

TREATMENT AND COURSE

As a vascular anomaly in the gallbladder was suspected, a cholecystectomy was performed. The surgical specimen revealed an angioleiomyoma of the gallbladder. The postoperative course was without complications and there was no further haemobilia.

CONCLUSIONS

Haemobilia is a relatively rare cause of upper gastrointestinal bleeding. It is usually due to trauma (accidental or iatrogenic) to the liver or the biliary tract. Rarely, as in this case, it can be caused by a benign mesenchymal neoplasm. Clotting disorder in uraemia or intermittent heparin administration for dialysis may in this patient have contributed to the bleeding.

摘要

病史与检查结果

一名47岁接受肾透析的男性出现急性绞痛性上腹部疼痛,该患者还患有慢性复发性胰腺炎。体格检查发现他有轻微黄疸,触诊肝脏边缘时有轻微疼痛。几天后出现黑便,血红蛋白浓度从正常水平降至6.9g/dl。

检查

血清学检查未发现急性胰腺炎的证据,但生化检查提示胆汁淤积。超声检查显示肝内和肝外胆道增宽。内镜逆行胰胆管造影显示胆道出血(胆道出血)为出血来源。腹腔干选择性血管造影显示胆囊区域有造影剂外渗。

治疗与病程

由于怀疑胆囊存在血管异常,遂行胆囊切除术。手术标本显示为胆囊血管平滑肌瘤。术后病程无并发症,未再出现胆道出血。

结论

胆道出血是上消化道出血相对少见的原因。通常是由于肝脏或胆道受到创伤(意外或医源性)。在本例中,罕见地由良性间叶性肿瘤引起。该患者的尿毒症凝血障碍或透析期间间歇性使用肝素可能促使了出血。

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