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钆喷酸葡胺磁共振脑池造影术在动物模型中的评估:初步报告

Evaluation of gadopentetate dimeglumine magnetic resonance cisternography in an animal model: preliminary report.

作者信息

Jinkins J R, Williams R F, Xiong L

机构信息

Department of Radiology, The University of Texas Health Science Center, San Antonio 78284-7800, USA.

出版信息

Invest Radiol. 1999 Feb;34(2):156-9. doi: 10.1097/00004424-199902000-00009.

Abstract

RATIONALE AND OBJECTIVES

To evaluate magnetic resonance (MR) imaging characteristics of the cisternal administration of gadopentetate dimeglumine (gadolinium) in a small experimental animal.

METHODS

Four female New Zealand White rabbits were used for this experiment. Each rabbit received a single dose of intrathecal gadolinium (doses ranged from 75-100 micromol) via a cisternal puncture. Immediate and delayed sagittal and axial T1-weighted images of the brain and cervical spinal cord were acquired on a 2 Tesla CSI magnet.

RESULTS

All the rabbits tolerated the experiment well, without significant alterations in behavior or seizure activity. During the early phase of imaging, subarachnoid space enhancement was observed over the surface of the brain parenchyma and spinal cord on T1-weighted images. Gradual diffusion of the gadolinium into the cranial parenchyma was seen on the delayed MR studies (45 minutes-6 hours), as revealed by progressive generalized enhancement of the brain. Sustained enhancement of gray matter of the spinal cord was observed.

CONCLUSION

This study illustrates that there is no barrier between the cerebrospinal fluid (CSF) and the brain-spinal cord with regard to gadolinium. Possible practical applications for gadolinium-enhanced MR myelography or cisternography include the assessment of communication or obstruction of CSF pathways, subarachnoid space CSF flow pattern analysis, spontaneous or acquired CSF fistula evaluation, evaluation of the intercommunication of central nervous system cystic structures bordering on CSF pathways, and the study of the dynamics of gadolinium diffusion in the central nervous system parenchyma.

摘要

原理与目的

评估在小型实验动物中经脑池注射钆喷酸葡胺(钆)后的磁共振(MR)成像特征。

方法

本实验使用4只雌性新西兰白兔。每只兔子通过脑池穿刺接受单次鞘内注射钆(剂量范围为75 - 100微摩尔)。在2特斯拉的CSI磁体上获取大脑和颈脊髓的即时及延迟矢状位和轴位T1加权图像。

结果

所有兔子对实验耐受良好,行为或癫痫活动无明显改变。在成像早期,T1加权图像上可见蛛网膜下腔在脑实质和脊髓表面强化。在延迟的MR研究(45分钟 - 6小时)中,可见钆逐渐扩散至脑实质,表现为大脑逐渐出现广泛强化。观察到脊髓灰质持续强化。

结论

本研究表明,在钆方面,脑脊液(CSF)与脑脊髓之间不存在屏障。钆增强MR脊髓造影或脑池造影的可能实际应用包括评估CSF通路的连通或梗阻、蛛网膜下腔CSF流动模式分析、自发性或后天性CSF瘘评估、评估毗邻CSF通路的中枢神经系统囊性结构的相互连通,以及研究钆在中枢神经系统实质中的扩散动力学。

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