Yokoo H, Nakazato Y, Fukuyama H, Miyaishi O, Sato T
First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan.
Pathol Int. 1998 Dec;48(12):985-8. doi: 10.1111/j.1440-1827.1998.tb03871.x.
An autopsy case of retroperitoneal leiomyosarcoma of a centenarial male is described. He complained of abdominal pain in his left side 1 month before his death. Ultrasonography and computed tomography revealed a large mass in the left abdominal cavity. At autopsy, a circumscribed mass, 15 cm in diameter, was found in the left-upper abdominal cavity, and seemed to be derived from the retroperitoneum in an exophytic manner. Histologically, spindle cells with slight eosinophilic cytoplasm and blunt-ended nuclei showed interwoven fascicular growth, and mitotic figures were easily encountered. Immunohistochemically, the tumor cells were labeled by alpha-smooth muscle actin and vimentin. To our knowledge, this case of leiomyosarcoma has presented in the oldest patient ever reported. The rarity of soft tissue sarcomas in the extremely elderly is also discussed.
本文描述了一例百岁男性腹膜后平滑肌肉瘤的尸检病例。他在去世前1个月主诉左侧腹痛。超声检查和计算机断层扫描显示左腹腔有一个大肿块。尸检时，在左上腹腔发现一个直径15厘米的边界清楚的肿块，似乎以向外生长的方式起源于腹膜后。组织学上，梭形细胞胞质轻度嗜酸性，核钝圆，呈交织束状生长，易见核分裂象。免疫组化显示，肿瘤细胞被α-平滑肌肌动蛋白和波形蛋白标记。据我们所知，该例平滑肌肉瘤患者是有报道以来年龄最大的。同时也讨论了软组织肉瘤在极高龄患者中的罕见性。
