Kameyama K, Mukai M, Iri H, Kuramochi S, Yamazaki K, Ikeda Y, Hata J
Division of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan.
Pathol Int. 1998 Dec;48(12):994-7. doi: 10.1111/j.1440-1827.1998.tb03873.x.
Approximately 100 female secretory carcinoma cases have been reported. Although this tumor was initially termed juvenile carcinoma as the patients were all children and adolescent females, subsequent reports demonstrated that it occurs in females of all ages. Moreover, to date, only five males with this tumor have been reported. As with the initial female secretory carcinoma cases, all five were children or young adults. A very rare case of non-invasive secretory carcinoma of the breast arising in a 51-year-old Japanese male is described. He presented with a lump in his left breast. The surgically resected tumor was a typical secretory carcinoma histologically, except that there was no infiltration of the surrounding stroma, and was composed of tumor cells with vacuolated cytoplasm that contained secretory materials. This case, the first recorded secretory carcinoma of the breast in a middle-aged male, demonstrates that this tumor may also arise in mature males, as is the case in females. Physicians should not rule out the possibility of a secretory carcinoma of the breast regardless of patient age and gender.
据报道，大约有100例女性分泌性癌病例。尽管这种肿瘤最初被称为幼年型癌，因为患者均为儿童和青春期女性，但随后的报告表明，它可发生于所有年龄段的女性。此外，迄今为止，仅报告了5例男性患有这种肿瘤。与最初的女性分泌性癌病例一样，这5例均为儿童或青年男性。本文描述了1例极为罕见的发生于一名51岁日本男性的非侵袭性乳腺分泌性癌。他因左乳肿块就诊。手术切除的肿瘤在组织学上是典型的分泌性癌，只是未侵犯周围基质，由具有空泡状细胞质且含有分泌物质的肿瘤细胞组成。该病例是首例有记录的中年男性乳腺分泌性癌，表明这种肿瘤也可能发生于成年男性，如同在女性中一样。无论患者年龄和性别如何，医生都不应排除乳腺分泌性癌的可能性。
