Bernard N F, Yannakis C M, Lee J S, Tsoukas C M
Immunodeficiency Treatment Center, McGill University Hospital Center, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada.
J Infect Dis. 1999 Mar;179(3):538-47. doi: 10.1086/314621.
Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against progressive infection with HIV is important for vaccine development. Nineteen subjects at risk for HIV infection were CCR-5 genotyped and screened for virus-specific memory cytotoxic T lymphocytes (CTL). None had the Delta32CCR-5/Delta32CCR-5 genotype associated with HIV resistance. HIV-specific CTL were detected in 7 (41.1%) of 17 exposed uninfected subjects versus 0 of 14 seronegative subjects with no HIV risk factors (P=.006, chi2 test). Recognition of virus by CTL in exposed uninfected subjects was major histocompatibility complex class I-restricted and multispecific, and specificity could change with time. Activity could persist up to 34 months after the last virus exposure. The presence of HIV-specific CTL in a greater proportion of seronegative HIV-exposed versus unexposed subjects supports the notion that in some cases, virus exposure induces HIV immunity without seroconversion or disease progression.
反复接触人类免疫缺陷病毒（HIV）并不总会导致血清转化。了解允许或预防HIV进行性感染的条件对于疫苗研发至关重要。对19名有HIV感染风险的受试者进行了CCR - 5基因分型，并筛查了病毒特异性记忆细胞毒性T淋巴细胞（CTL）。没有人具有与HIV耐药性相关的Delta32CCR - 5/Delta32CCR - 5基因型。在17名暴露但未感染的受试者中有7名（41.1%）检测到HIV特异性CTL，而在14名无HIV风险因素的血清阴性受试者中未检测到（P = 0.006，卡方检验）。暴露但未感染的受试者中CTL对病毒的识别受主要组织相容性复合体I类限制且具有多特异性，并且特异性可能随时间变化。活性在最后一次病毒暴露后可持续长达34个月。与未暴露的受试者相比，在更大比例的血清阴性且暴露于HIV的受试者中存在HIV特异性CTL，这支持了在某些情况下，病毒暴露可诱导HIV免疫而不发生血清转化或疾病进展这一观点。
