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[与电解质紊乱相关的紧急情况。特殊方面]

[Emergency stiuations connected with electrolyte disorders. Special aspects].

作者信息

Truniger B

出版信息

Minerva Med. 1976 Nov 14;67(55):3637-42.

PMID:995309
Abstract

Electrolyte-induced situations which are dangerous to life usually result from disturbances of the extracellular volume (ECV), osmolarity, the potassium level or the acid-base equilibrium. In recent years (thanks to the wide spread use of hormone therapy for mammary carcinoma) severe hypercalcemia has increased in importance as a life-threatening complication, while hypocalcemia, at least in adults, should only very seldom lead to unexpected emergencies. As long as serious clinical symptoms do not suggest an emergency, assessment of the threat to the patient as a result of the existing electrolyte disturbance often causes some difficulty. Besides the extent of the deviation from normal, the rate of development of the disturbance determines the resulting danger: chronic hypo-osmolarity, and especially hyperosmolarity are occasionally tolerated without symptoms while acute disturbances of the same or a less extent lead to severe central nervous symptoms. A similar state of affairs is also true of the emergency situations arising from disturbances of the acid-base equilibrium, among which the respiratory disorders are particularly important clinically. In the case of threatening disorders of the potassium metabolism, the accompanying circumstances (digitalis, simultaneous disorders and treatment of the acid-base equilibrium) often determine the clinical significance and danger to the patient. Clinical symptoms, anticipation ("expecting the unexpected"), prevention and treatment of emergency situations of fluid volume, osmolarity, potassium and acid-base equilibrium are the subjects of this paper.

摘要

对生命有危险的电解质紊乱情况通常是由细胞外液量(ECV)、渗透压、钾水平或酸碱平衡的失调引起的。近年来(由于乳腺癌激素疗法的广泛应用),严重高钙血症作为一种危及生命的并发症,其重要性日益增加,而低钙血症,至少在成年人中,很少会导致意外紧急情况。只要严重的临床症状不提示紧急情况,评估现有电解质紊乱对患者的威胁往往会有些困难。除了与正常水平的偏差程度外,紊乱的发展速度也决定了由此产生的危险:慢性低渗,尤其是高渗,有时可无症状耐受,而相同程度或较小程度的急性紊乱则会导致严重的中枢神经症状。酸碱平衡失调引起的紧急情况也类似,其中呼吸紊乱在临床上尤为重要。在有威胁的钾代谢紊乱情况下,伴随情况(洋地黄、同时存在的紊乱以及酸碱平衡的治疗)往往决定了对患者的临床意义和危险。本文的主题是液体量、渗透压、钾和酸碱平衡紧急情况的临床症状、预判(“预料到意外情况”)、预防和治疗。

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