含硫代嘧啶的多聚核糖核苷酸对干扰素的诱导作用。

Induction of interferon by polyribonucleotides containing thiopyrimidines.

作者信息

Reuss K, Scheit K H, Saiko O

出版信息

Nucleic Acids Res. 1976 Oct;3(10):2861-75. doi: 10.1093/nar/3.10.2861.

DOI:10.1093/nar/3.10.2861

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343133/

Abstract

The influence of thioketo substitution in pyrimidine bases of double-stranded polynucleotides on interferon induction was investigated. The stabilizing effect of 2-thioketo substitution was reflected in the increased interferon inducing activity of poly(A-s2U) over that of poly(A-U). Poly(A-s2U) and poly(I)-poly(s2C) were as effective as poly(I)-Poly(C) in rabbit cells. Poly(I)-poly(C) and poly(I)-poly(s2C) were compared in several animal species. No differences in biological effects were observed in rabbits and dogs. In rodents, poly(I)-poly(s2C) was less effective and less toxic.Poly(I)-poly(s2C) was highly resistant against degradation by human serum. Further investigations seem to be justified to elucidate whether this property offers any advantages for the potential clinical utilization of poly(I)-poly(s2C).

摘要

研究了双链多核苷酸嘧啶碱基中的硫酮取代对干扰素诱导的影响。2-硫酮取代的稳定作用体现在聚（A-s2U）的干扰素诱导活性高于聚（A-U）。聚（A-s2U）和聚（I）-聚（s2C）在兔细胞中与聚（I）-聚（C）一样有效。在几种动物物种中比较了聚（I）-聚（C）和聚（I）-聚（s2C）。在兔和狗中未观察到生物学效应的差异。在啮齿动物中，聚（I）-聚（s2C）效果较差且毒性较小。聚（I）-聚（s2C）对人血清降解具有高度抗性。进一步的研究似乎有必要阐明该特性是否为聚（I）-聚（s2C）的潜在临床应用提供任何优势。

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Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus.干扰素的生物学研究。I. 东部马脑脊髓炎病毒细胞感染的抑制

Virology. 1961 Mar;13:323-37. doi: 10.1016/0042-6822(61)90152-0.

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Synthesis and properties of poly-2,4-dithiouridylic acid, a new analog of poly uridylic acid.聚尿苷酸的一种新类似物——聚-2,4-二硫代尿苷酸的合成与性质

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Interferon induction increased through chemical modification of a synthetic polyribonucleotide.通过对合成多聚核糖核苷酸进行化学修饰，干扰素诱导作用增强。

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Induction of interferon by preparations of synthetic single-stranded RNA.合成单链RNA制剂诱导干扰素的产生。

Proc Natl Acad Sci U S A. 1969 Sep;64(1):67-74. doi: 10.1073/pnas.64.1.67.

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J Mol Biol. 1972 Oct 14;70(3):567-87. doi: 10.1016/0022-2836(72)90560-8.

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A new polynucleotide complex poly(s 2 C)-poly(I).一种新的多核苷酸复合物聚（s2C）-聚（I）。

Eur J Biochem. 1972 May;27(1):109-15. doi: 10.1111/j.1432-1033.1972.tb01816.x.

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Synthesis and properties of poly(s 2 C), a new poly(C) analog.新型聚（C）类似物聚（s2C）的合成与性质

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9

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Med Clin North Am. 1971 May;55(3):721-8. doi: 10.1016/s0025-7125(16)32513-5.

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Proc Soc Exp Biol Med. 1971 Apr;136(4):1180-6. doi: 10.3181/00379727-136-35454.

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