精神分裂症药物评估。基础试验设计。
Assessment of drugs in schizophrenia. Basic trial design.
作者信息
Lader M
出版信息
Br J Clin Pharmacol. 1976 Jun;3(3 Suppl 2):375-9. doi: 10.1111/j.1365-2125.1976.tb03728.x.
Abstract
Clinical trials with major tranquilizers must take into account the clinical features of patients with schizophrenia and pharmacokinetic and pharmacodynamic properties of the drug. The objectives of the trial must be carefully defined so that appropriate selection criteria for patients, rating instruments and dosage schedules can be selected. It is useful to monitor physiological and biochemical actions of major tranquilizers as well as the clinical effects.
摘要
使用主要镇静剂的临床试验必须考虑精神分裂症患者的临床特征以及药物的药代动力学和药效学特性。必须仔细界定试验目标，以便能够选择合适的患者入选标准、评定工具和给药方案。监测主要镇静剂的生理和生化作用以及临床效果很有必要。
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本文引用的文献
1
Sudden removal of tranquilizing drugs from chronic psychiatric patients.
J Nerv Ment Dis. 1960 Sep;131:252-5. doi: 10.1097/00005053-196009000-00007.
2
Riboflavine as an indicator of drug taking behaviour.
Med J Aust. 1967 Feb 4;1(5):202-4. doi: 10.5694/j.1326-5377.1967.tb21152.x.
3
Physiologic and clinical effects of chlorpromazine and their relationship to plasma level.氯丙嗪的生理和临床效应及其与血浆水平的关系。
Clin Pharmacol Ther. 1972 Nov-Dec;13(6):931-46. doi: 10.1002/cpt1972136931.
4
Clinical biostatistics. XIV. The purposes of prognostic stratification.临床生物统计学。十四、预后分层的目的。
Clin Pharmacol Ther. 1972 Mar-Apr;13(2):285-97. doi: 10.1002/cpt1972132285.
5
Integrating psychiatric research with clinical training: N=1.将精神病学研究与临床培训相结合：样本量N = 1。
J Nerv Ment Dis. 1972 Mar;154(3):206-12. doi: 10.1097/00005053-197203000-00010.
6
Trial of maintenance therapy in schizophrenia.精神分裂症维持治疗试验
Br Med J. 1971 Sep 11;3(5775):599-604. doi: 10.1136/bmj.3.5775.599.
7
Life events and psychiatric disorders. 2. Nature of causal link.
Psychol Med. 1973 May;3(2):159-76. doi: 10.1017/s0033291700048492.
8
Life-events and psychiatric disorders. 1. Some methodological issues.
Psychol Med. 1973 Feb;3(1):74-87. doi: 10.1017/s0033291700046365.
9
Influence of selection of patients on results of clinical trials.患者选择对临床试验结果的影响。
Br Med J. 1973 Oct 20;4(5885):156-8. doi: 10.1136/bmj.4.5885.156.
10
Role of fluphenazine decanoate in lessening the burden of chronic schizophrenics on the community.
Psychol Med. 1973 May;3(2):141-58. doi: 10.1017/s0033291700048480.
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