患者选择对临床试验结果的影响。
Influence of selection of patients on results of clinical trials.
作者信息
Leff J P
出版信息
Br Med J. 1973 Oct 20;4(5885):156-8. doi: 10.1136/bmj.4.5885.156.
Abstract
The hypothesis is advanced that any population of patients can be divided into those with a good prognosis, a poor prognosis, and an intermediate prognosis in respect to a particular treatment. The outcome of a clinical trial of treatment will be partly determined by the proportion of patients selected for the trial from each of these prognostic groups. The implications of the hypothesis are illustrated by consideration of three recent trials of treatment for psychiatric patients.
摘要
有一种假设认为，对于某种特定治疗而言，任何患者群体都可分为预后良好、预后不良和预后中等的三类。治疗临床试验的结果将部分取决于从这些预后组中入选试验的患者比例。通过对近期三项精神病患者治疗试验的考量，该假设的影响得以阐明。
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本文引用的文献
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Outpatient maintenance of chronic schizophrenic patients with long-acting fluphenazine: double-blind placebo trial. Report to the Medical Research Council Committee on Clinical Trials in Psychiatry.长效氟奋乃静对慢性精神分裂症患者的门诊维持治疗：双盲安慰剂试验。提交给医学研究委员会精神病学临床试验委员会的报告。
Br Med J. 1973 Mar 17;1(5854):633-7. doi: 10.1136/bmj.1.5854.633.
2
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